One fateful day, all of humanity was petrified by a blinding flash of light. After several millennia, high schooler Taiju awakens and finds himself lost in a world of statues. However, he's not alone! His science-loving friend Senku's been up and running for a few months and he's got a grand plan in mind—to kickstart civilization with the power of science!
Thousands of years after a mysterious phenomenon turned all of humanity to stone, the super-intelligent, science-driven boy Senku Ishigami awakens. Facing a world of stone and the total collapse of civilization, Senku decides to use science to rebuild the world. Together with his childhood friend Taiju Oki, they begin to rebuild civilization from scratch.
Senku and Taiju prepare to make Yuzuriha as the first person they revive with their completed water, only to suddenly be chased by lions. In order to fight them off, the duo decide to instead revive the strongest fighter in their school, Tsukasa Shishio, who proves to be a valuable hunter. As the group begin harvesting seashells to grind into calcium carbonate for further advances in civilization, Tsukasa, who is against reviving the corrupt adults of human society, clashes with Senku, who remains determined to save everyone.
Senku does not trust the motivation of Shishio, so he will try to hide his plans from a new and unforeseen enemy for his plan to revive civilization.
The group embarks on a hunt for gunpowder making supplies; an accidental explosion leads to a fight.
Taiju and Yuzuriha flee from Tsukasa while taking Senku with them. It is discovered how Senku survived his first days after being freed from petrifaction.
Senku awakens after being nearly killed by Tsukasa and suggests splitting up with Yuzuriha and Taiju so they can spy on Tsukasa. A girl fights Tsukasa but is defeated and trapped under a tree. Senku finds the same girl and helps her.
Senku helps Kohaku bring hot water back to her village for her ill sister. Kohaku tells Senku about her village and that it has forty people. Senku is told he cannot enter the village. Senku explains to Chrome about the history of mankind.
Senku wants to make antibiotics and he explains how to Chrome and Kohaku. Senku decides to use magnets to collect iron. A child named Suika offers to help Senku. Senku decides to make ramen to appease the villagers and use their manpower.
Senku feeds the villagers ramen so they can help him make iron. Senku meets Asagiri Gen a man who's been unpetrified and is working for Tsukasa. Asagiri decides to help Senku. Senku wants to make a generator with the help of lightning.
After Gen is brutally beaten in a surprise attack, Kohaku devises a plan to bring down the attacker once and for all.
Suika never wants to show her face for some reason that only a few know. Fortunately, Senku knows the solution to his annoying problem.
To recover the most problematic ingredient in order to create sulfonamides, Ginro, Chrome, Kohaku and Senku will head to a zone of maximum danger. What kind of enemy will stand before them?
All that's needed to make antibiotics is alcohol. The best way to get some is to win the Grand Bout, which the Senku and his kingdom will also need to do in order to keep Magma away from Ruri and give her the drug.
After Magma's series of tricks to reach the final match, Chrome reveals a trick of his own. With a little extra help from Gen, Chrome just may be able to pull this one off.
After Senku's unlikely victory, quick marriage, and even hastier divorce, the kingdom of science is back to work to finally finish Ruri's medicine.
Ruri reveals the origin of the village's name and Senku learns of his father's fate.
Byakuya and the astronauts' story continues, and Senku's connection to Ishigami Village and the Hundred Tales is finally revealed.
Tsukasa's army is coming. Kinro struggles to hold the bridge against the deadly spearman Hyoga and his shock troops, but Senku and the villagers are ready with deadly new weapons of science.
Hyoga is disarmed, but the kingdom of science is still in danger - Ishigami village is in flames. And Tsukasa will soon know that Senku is still alive - How will the villagers fight off the coming invasion?
Work begins on creating the components for Senku's cell phone, but spinning gold wire is proving to be quite the task! Luckily, Chrome and Kaseki "invent" the water wheel and drastically improve the process!
With Chrome and Kaseki's water wheel finished, Ishigami Village moves into the age of electricity! But with the primitive materials available to him, will Senku be able to create a filament that can withstand the intense heat of operating a vacuum tube?
Senku, Chrome, and Magma venture into a cave in search of Tungsten, but there's a suspicious accident that leaves Senku and Chrome trapped at the bottom of a pit! What is Magma up to?!
Senku and the rest of the village get to work on making the components for the cell phone. It's hard work but everyone is pumped!
In a flashback, Byakuya decides to leave a glass record for Senku containing a message from him. In the present, Senku and his group create a record player.Senku unveils the record player to the village and plays it. To their amazement, Byakuya's voice is heard as he introduces himself. He then stops with the formalities as he addresses Senku, knowing full well that he is free by now and is hearing the message. Byakuya wants to voice confidence in him before stopping, since he knows his son wouldn't go for sappy father-son moments. Senku laughs that Byakuya truly gets him, as Kohaku notes that Senku is cold to his father while Kokuyo sadly notes she is no better.Byakuya then has Lillian perform a song preformed with the crew helping. The villagers are in awe at the sound.
Senku continues in trying to advance the stone world, this time he makes "space food", it is in actuality cup noodles. After Senku finishes his project, Gen has an epiphany and devises a plan to take down Tsukasa's army without violence.
While Senku's diversion buys Gen and others some time, soon Homura realizes something is not right.
Ishigami village takes up agriculture.
The Kingdom of Science needs rations for the planned voyage of discovery.
Senku looks for the Sagara oil fields.
Senku and his companions finally set off for America in search of corn. However, a dispute arises between Ryusui and Senku shortly after they depart
Maintaining morale will be critical on the long journey to the Americas. Knowing where on the ocean you are is pretty important, too. The crew of the Perseus discuss.
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Taiju and Yuzuriha are on the verge of tears after they hear Senku's voice, and Senku informs them of his plan to win the war without any bloodshed.
Chrome and Magnum struggles with Urkyo, while Senku, however, gets his hands busy with building up an invention; a new hope.
The final touches to the automobile are made and it is used to transport the science supplies to a fortified cliffside that's close to the Tsukasa empire. From there the automobile is upgraded into a tank, but unbeknownst to the rescue group preparations by the empire have been made to counter any vehicular attack.
Desperate to escape his prisone confine, Chrome tries to stratergize a plan that will allow him to escape. However, surrounding his prison are traps and his new head jailer Yo is a former loose cannon police officer.
With Chrome safe and sound, Senku and Gen start work on the plan to convert people to their side with the Lilian Weinberg recording. They just have to avoid Ukyo and his incredible hearing.
The Final Battle for the miracle cave starts as Senku and the Kingdom of Science conduct a frontal assault on the cave.
Tsukasa and Hyoga are coming to capture the miracle cave. The Kingdom of Science must buy Senku and Chrome some time to turn the tide, or it is all over.
A truce is called between the Kingdom of Science and Tsukasa Empire. All appears to be well, but some of the Kingdom's dynamite is missing.
The Kingdom of Science is victorious, however it is not over for Senku. Senku must use all of his knowledge to cure Tsukasa who is severly injured.
The Kingdom of Science creates radar and sonar to determine the source of the morse code.
Kaseki's efforts to build the Perseus hits a roadblock.
The ship Perseus is completed, then the Perseus sets sail to the Treasure Island with a select Ishigami crew on board. Dr. Stone and the others goal is a island where the ISS space station crew landed years in the past.
The Perseus arrives at the Treasure Island.
Amaryllis explains how she avoided being petrified and how she decided to sneak into the palace.
Suika and Ginro strive to rescue the mobile lab from the Perseus.
Amaryllis, Ginro and Kohaku are chosen to join the inner palace. The science team will need a way to communicate with them in secret, and, eventually, a way for them with the science team.
Kohaku has located the treasure left behind by Byakuya and the others, but it's encased in concrete. Senku has to devise a plan to quietly get at the contents inside, so as to not alert the guards.
Kohaku is forced to destroy Ryusui's statue to prove that she isn't a spy.
The team revives Kaseki to work on the drone. Meanwhile, Ginro is called to see the Master.
More of the Kingdom of Science is brought back from petrification, but they are discovered in the cave by Moz.
Moz and the Kingdom of Science form a tenuous, temporary alliance against Ibara. How long it will last is a question they can't afford to concern themselves with just yet.
The Kingdom of Science attacks and tries to execute their plan to steal the petrification device. Moz convinces Kirisame to use the device, but Ryusui's instincts tell him something is off about the situation.
The Kingdom of Science members launch an attack on the islanders aboard the Perseus, but Moz isn't far behind and Senku and the others are forced to retreat inside the vessel. Ibara has them cornered, but Senku unleashes his Joker card.
Yo and the Kingdom of Science capture the petrification device, but Ibara isn't going down without a fight.
Much to Ibara's shock and dismay, Senku devised a plan and managed to escape petrification. Now the two enter into a head-to-head battle for control of the Medusa device.
Senku stands victorious. He then works on reviving the others and fixing their communications device, but while they are talking with Ruri they encounter a strong interference with the signal.
To the moon! That's the plan, at least. Senku and the Kingdom of Science need to devise a means with which to go to the moon and deal with Why-Man. The first step is allying with the people of Treasure Island and enlisting their help with some new crafts.
With the petrification device in the Kingdom's hands, it's time to revive Tsukasa. But there's just one problem: the device is out of batteries.
The Perseus lands in the Americas. They first head to Northern California in search of yellow dent corn, but discover a lot more than that.
The search party narrowly escaped enemy machine gun fire. Unfortunately, the respite was short-lived.
Tensions rise as Dr. Xeno makes his introductions to the Perseus.
Stanley orders Luna to infiltrate the Perseus and identify Doctor Taiju. Things go sideways when it turns out to be a little too easy.
Senku had gotten his start in rocket building through an email exchange with Doctor Xeno. Their approaches to science soon diverged.
NASA scientist Dr. Xeno attempts to pick off the leader of the Kingdom of Science.
With the crew on board tending to a severely injured Senku, Chrome's team and Tsukasa's team must join forces to devise a way to infiltrate the enemy's lair.
With Senku still confined to the bed, Chrome's team begins work on the tunnel to Xeno's base.
Ryusui and Senku take to the skies in a science versus science dogfight while Xeno's forces mount a ground counterattack.
Xeno's army attacks and when all seems lost, Chrome and his friends finish the tunnel and capture Xeno.
The team head to the source of the petrification beam in South America as they flee from Stanley's ship.
Senku and company must flee from Stanley's ship, but they have to make stops to refuel.
After falling for a decoy, Stanley's team finally catches up to the crew, who must now outwit them while racing through the desert.
The team is going to need a weapon for when Stanley inevitably catches up to them.
Senku and his team have lost Stanley for now, but they aren't out of -- or rather, in -- the woods just yet.
The team discovers a giant pile of petrification devices. They take them apart to see what makes them tick.
The team begins making, digging for, and polishing diamonds to replace the burnt-out ones inside the devices.
Suika is in charge of making sure Senku's plan works, but her kindness becomes an obstacle.
With the revival team captured, it's up to Luna and Chelsea to revive everyone when the time comes.
With the petrification beam approaching, who will get their hands on the revival fluid?
Suika gathers the team's statues, sets up camp and gets to work doing science.
With Senku back, it's only a matter of time before the rest of the Kingdom of Science is revived.